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The fear of the LORD is the beginning of knowledge: but fools despise wisdom and instruction.
– Proverbs 1:7
Understanding the right relation to God illuminates the meaning of fools despising wisdom and instruction. Fools want wisdom, but they want it separate from God (Psalm 14:1). So their despising is a despising of true wisdom. The fool’s pursuit ends in less knowledge and wisdom (Romans 1:18-32).